The interplay between hormonal vitamin D and lipopolysaccharide signaling on human neutrophil transcriptional responses
Collectively, the data suggest that LPS prolongs vitamin D signaling by suppressing expression of the 1,25D catabolic enzyme CYP24A1. 1,25D signaling in the presence of LPS attenuates the expression of several genes associated with LPS inflammatory responses, whereas 1,25D in the absence or presence of LPS enhances the release of antibacterial proteins secreted by neutrophils in response to infection.
Authors
- Volker Blank (ORCID: https://orcid.org/0000-0002-7029-2462)
- James Saliba (ORCID: https://orcid.org/0000-0003-0450-9616)
- John H. White (ORCID: https://orcid.org/0000-0002-4785-2687)
- Aiten Ismailova (ORCID: https://orcid.org/0000-0001-5530-5336)
- Reyhaneh Salehi-Tabar (ORCID: https://orcid.org/0000-0002-9111-6513)
- O Dumas
- Nailya Ismailova (ORCID: https://orcid.org/0000-0002-8683-9178)
Institutions
- McGill University (CA)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-03
- DOI
- https://doi.org/10.3389/fimmu.2025.1683913
- Citations
- 1
- Primary Topic
- Vitamin D Research Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.47
Funders
- McGill University
- Canadian Institutes of Health Research