Toll-like receptor activation and gene delivery efficiency in canine dendritic cells: a model for comparative oncology
Our findings demonstrate that cmDCs derived from both HDs and TbDs are phenotypically and functionally competent and can be efficiently transfected using a non-viral mRNA delivery system. This strategy offers a viable platform for the development of personalized, DC-based cancer vaccines in canine patients.
Authors
- Sara E. Bellomo (ORCID: https://orcid.org/0000-0001-5738-2351)
- Letizia Nicoletti (ORCID: https://orcid.org/0000-0003-4423-0716)
- Raffaella De Maria (ORCID: https://orcid.org/0000-0002-7028-2280)
- Lorenza Parisi (ORCID: https://orcid.org/0000-0001-6684-6859)
- Enrico Berrino (ORCID: https://orcid.org/0000-0001-6728-5619)
- Valeria Chiono (ORCID: https://orcid.org/0000-0003-2067-7732)
- Eugenio Mazzone (ORCID: https://orcid.org/0009-0001-6161-5311)
- Lisa Adele Piras (ORCID: https://orcid.org/0000-0002-0788-0376)
- Caterina Marchiò (ORCID: https://orcid.org/0000-0003-2024-6131)
- Luca Aresu (ORCID: https://orcid.org/0000-0002-7893-1740)
- Sonia Capellero (ORCID: https://orcid.org/0000-0001-9043-9014)
- Laura Marconato (ORCID: https://orcid.org/0000-0002-7843-615X)
- Anna Sapino (ORCID: https://orcid.org/0000-0003-3542-9571)
- Giovanni Paolo Stola
Institutions
- Politecnico di Torino (IT)
- Torino e-district (IT)
- Candiolo Cancer Institute (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- University of Turin (IT)
- University of Bologna (IT)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-03
- DOI
- https://doi.org/10.3389/fimmu.2025.1678896
- Primary Topic
- Immunotherapy and Immune Responses
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Politecnico di Torino
- Ministero della Salute
- Fondazione Umberto Veronesi
- Università degli Studi di Torino