Molecular insights of drug-resistant tuberculosis: genetic mutations and their profile

The high prevalence of mutations such as <i>rpo</i>B MUT3 (S531L) and <i>kat</i>G MUT1 (S315T1) highlights the need for integrating molecular tools into routine workflows to identify genetic mutations. District-specific mutations emphasize the influence of local epidemiological factors on resistance patterns, necessitating region-specific interventions. Continuing research into regional resistance trends are vital to addressing the global DR-TB burden effectively.