Mechanistic Exploration of Shenling Baizhu Powder in Treating Irinotecan-Associated Diarrhea: A Study Based on Network Pharmacology and Experimental Validation
Integrated network pharmacology analysis and experimental validation demonstrate that SLBZP alleviates IAD primarily by suppressing intestinal inflammatory responses, providing mechanistic evidence to support its clinical application in managing chemotherapy-induced intestinal toxicity.
Authors
- Ying Xiong (ORCID: https://orcid.org/0000-0002-5680-9269)
- Zhiqiang Cheng
- Jun Yuan (ORCID: https://orcid.org/0000-0001-6542-4654)
- Rubing Shi (ORCID: https://orcid.org/0009-0009-0024-2353)
- Meng Liu (ORCID: https://orcid.org/0000-0003-2513-7866)
- Jin Qi (ORCID: https://orcid.org/0000-0003-2972-5075)
- Jincheng Zhang (ORCID: https://orcid.org/0000-0001-7332-6704)
Institutions
- Beijing University of Chinese Medicine (CN)
- China-Japan Friendship Hospital (CN)
Publication Details
- Journal
- Journal of Inflammation Research
- Published
- 2025-10-01
- DOI
- https://doi.org/10.2147/jir.s536184
- Citations
- 1
- Primary Topic
- Pharmacological Effects of Natural Compounds
- Type
- article
- Field-Weighted Citation Impact
- 1.56