Design And Characterization of Mucoadhesive Buccal Patches of Repaglinide

Repaglinide is an antidiabetic drug which belongs to the class of Meglitinides .the main aim of the study is to develop and characterise mucoadhesive buccal patches of Repaglinide to avoid first pass metabolism. The patches were prepared by solvent casting method and characterised for folding endurance,thickness,drug content,surface pH ,tensile strength, bioadhesive strength, in vitro drug release study etc. In vitro dissolution studies are conducted by using phosphate buffer 6.8 pH. The buccal patches were prepared by using the polymers chitosan, poly vinyl pyrrolidone, Hydroxyl propyl methyl cellulose, poly vinyl alcohol.Propylene glycol is used as plasticiser. The result of the study indicates tensile strength of patches were between 1.82-2.1N/m2. Folding endurance is between 189 to 245.Patches thickness were from 0.27-0.33mm .The swelling index is between 22.7 to 56.7. Bio adhesion time was from 4-6 hours. Buccal patches prepared with chitosan, PVP K-30, HPMC were exhibit prolong release for more than 8 hours. It is having case II transport mechanism. The drug release rate of all the formulation were analysed for Zero order, First order, Higuchi and Peppas equation. All the formulation follows case II transport and anomalous mechanism.