Variations in alcohol craving and negative mood during a clinical trial of ibudilast for alcohol use disorder
Consistent with prior research, ibudilast reduced neurobiological and self-report markers of craving, with female participants showing a stronger treatment response by trial endpoint. Despite shared neuroimmune correlates between negative mood and addiction, ibudilast did not alleviate negative mood symptoms beyond placebo effects.
Authors
- Lindsay R. Meredith (ORCID: https://orcid.org/0000-0001-7584-9488)
- Craig K. Enders (ORCID: https://orcid.org/0000-0002-7048-8369)
- Lara A. Ray
- Erica N. Grodin (ORCID: https://orcid.org/0000-0001-5528-4918)
Institutions
- University of California, Los Angeles (US)
- Neurobehavioral Systems (US)
Publication Details
- Journal
- Alcohol Clinical and Experimental Research
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1111/acer.70178
- Citations
- 2
- Primary Topic
- Tryptophan and brain disorders
- Type
- article
- Field-Weighted Citation Impact
- 1.16
Funders
- J.B. and M.K. Pritzker Family Foundation