Emergence, surge, and fading of the novel feline parvovirus Thr390Ala mutant in Egyptian cats during 2023: insights from a comprehensive full-length VP2 genetic analysis
Beyond expanding the global dataset with the largest number of Egyptian full-length VP2 sequences to date, this study highlights the Thr390Ala mutant as a classic example of evolutionary trade-off: it emerged and predominate during the first peak, potentially as an immune escape variant, but declined in the second peak, likely due to structural constraints and competition with fitter variants. Despite strong purifying selection, this case illustrates that FPV evolution is not entirely static. This underscores the need for continuous genetic monitoring to capture viral evolution in real time and inform effective control strategies.
Authors
- Xi Chen (ORCID: https://orcid.org/0000-0002-3057-0309)
- Manar M. Farouk (ORCID: https://orcid.org/0000-0002-0750-4151)
- Mary A.N. Sargious (ORCID: https://orcid.org/0000-0002-3239-2147)
- Momen M. Ali
- Ghada M. Khalil
- Nehal Shahen
- Murad Ali (ORCID: https://orcid.org/0000-0003-2312-8843)
- Mahmoud S. Safwat
- Reham Karam (ORCID: https://orcid.org/0000-0002-5126-0895)
- Haitham M. Amer (ORCID: https://orcid.org/0000-0002-0024-2451)
- Omar Saeed (ORCID: https://orcid.org/0000-0001-6432-0730)
- Samah Eid (ORCID: https://orcid.org/0000-0002-5947-2438)
- Ehab M. Abd-Allah
- Ahmad Zaki Anwer
- Amthal Ahmed Fouad
- Samah El-Sayed M
- Salma W. Abdelhaleem
Institutions
- Cairo University (EG)
- Mansoura University (EG)
- Zagazig University (EG)
- Saudi Center for Disease Prevention and Control (SA)
- Animal Health Research Institute (TW)
- Southwest Minzu University (CN)
Publication Details
- Journal
- BMC Veterinary Research
- Published
- 2025-10-03
- DOI
- https://doi.org/10.1186/s12917-025-05004-3
- Citations
- 3
- Primary Topic
- Virus-based gene therapy research
- Type
- article
- Field-Weighted Citation Impact
- 5.45
Funders
- Science and Technology Development Fund
- Southwest Minzu University