DNA‐mediated UCP1 overexpression in adipose tissue: A promising anti‐obesity gene therapy
The hADP promoter-modified plasmids selectively overexpress protein in adipose tissue. Overexpression of UCP1 driven by hADP promoter induces thermogenesis in mouse and human adipocytes in vitro. The hADP-Ucp1 OE treatment promotes thermogenesis and energy expenditure in mice. The hADP-Ucp1 OE treatment restrains the development of obesity and glucose intolerance in mice.
Authors
- Jin Li (ORCID: https://orcid.org/0000-0002-4325-9691)
- Zewei Zhao (ORCID: https://orcid.org/0000-0001-6731-0474)
- Zhonghan Yang (ORCID: https://orcid.org/0000-0002-3009-4074)
- Μolin Wang (ORCID: https://orcid.org/0000-0002-9150-7928)
- Siqi Liu (ORCID: https://orcid.org/0000-0001-9744-3681)
- Qingqing Liu (ORCID: https://orcid.org/0000-0002-6672-3194)
- Longyun Hu
- Qian Wu (ORCID: https://orcid.org/0000-0002-1164-6582)
- Jiejing Lin
- Bigui Song
Institutions
- Sun Yat-sen University (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
Publication Details
- Journal
- Clinical and Translational Medicine
- Published
- 2025-10-01
- DOI
- https://doi.org/10.1002/ctm2.70491
- Citations
- 3
- Primary Topic
- Adipose Tissue and Metabolism
- Type
- article
- Field-Weighted Citation Impact
- 3.49