Association Between Serum Syndecan 1 Levels and Metabolic Syndrome Parameters: A Comparative Cross‐Sectional Study
These findings suggest that SDC1 levels are higher in males with MetS, particularly those with hypertension and elevated ALT, and are positively associated with DBP in both the total study sample and the MetS+ HTN+ ALT+ group. There were no significant associations with other metabolic parameters. This indicates that SDC1 may serve as a gender-specific biomarker for vascular risk in MetS, potentially aiding clinicians in identifying high-risk MetS subjects.
Authors
- Maryam Saberi‐Karimian (ORCID: https://orcid.org/0000-0003-2314-0471)
- Niloofar Shabani
- Maryam Mohammadi‐Bajgiran
- Susan Darroudi (ORCID: https://orcid.org/0000-0002-5377-729X)
- Gordon A. Ferns (ORCID: https://orcid.org/0000-0002-0957-8349)
- Shima Tavalaie
- Ali Mottaghi‐Moghaddam
- Maziar Rahmani (ORCID: https://orcid.org/0000-0003-2945-4551)
- Majid Ghayour‐Mobarhan (ORCID: https://orcid.org/0000-0002-1081-6754)
- Artemis AzadAra
Institutions
- Brighton and Sussex Medical School (GB)
- Mashhad University of Medical Sciences (IR)
- Islamic Azad University, Mashhad (IR)
- Tehran University of Medical Sciences (IR)
Publication Details
- Journal
- Endocrinology Diabetes & Metabolism
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1002/edm2.70108
- Citations
- 1
- Primary Topic
- Proteoglycans and glycosaminoglycans research
- Type
- article
- Field-Weighted Citation Impact
- 1.15
Funders
- Mashhad University of Medical Sciences