Newly isolated bacteriophages show efficacy and phage-antibiotic synergy in vitro against the equine genital pathogens Klebsiella pneumoniae and Pseudomonas aeruginosa
Phages against the equine genital pathogens K. pneumoniae and P. aeruginosa were evaluated in vitro for potential clinical use. While the bactericidal activity of the isolated phages was demonstrated in liquid culture, none of the tested phages showed significant reduction in in vitro biofilm models. However, due to synergistic activities between phages and antibiotics, further studies on combinatorial approaches are needed to develop strategies for managing difficult infections.
Authors
- Martin Köhne (ORCID: https://orcid.org/0000-0002-5442-2597)
- Anna Tönißen (ORCID: https://orcid.org/0009-0009-5446-2108)
- Juliane Hirnet (ORCID: https://orcid.org/0000-0003-0036-4835)
- Elisa Peh (ORCID: https://orcid.org/0000-0002-6573-4916)
- Harald Sieme (ORCID: https://orcid.org/0000-0001-9658-8790)
- Madeleine Plötz
- Mathias Müsken (ORCID: https://orcid.org/0000-0002-5624-1378)
- Sophie Kittler (ORCID: https://orcid.org/0000-0001-6295-5935)
- Ronja Hüsch
Institutions
- University of Veterinary Medicine Hannover, Foundation (DE)
- Helmholtz Centre for Infection Research (DE)
Publication Details
- Journal
- BMC Veterinary Research
- Published
- 2025-10-03
- DOI
- https://doi.org/10.1186/s12917-025-04989-1
- Citations
- 1
- Primary Topic
- Bacteriophages and microbial interactions
- Type
- article
- Field-Weighted Citation Impact
- 1.72
Funders
- Stiftung Tierärztliche Hochschule Hannover