Study on the influencing factors of the first-line treatment response to primary immune thrombocytopenia in children
Elevated P-gp and PLR, along with reduced CD4<sup>+</sup>/CD8<sup>+</sup> ratio and C3 levels, are independent risk factors for GC treatment failure in children with ITP. For IVIG therapy, increased PLR and IgG levels are associated with poor response. These indicators demonstrate predictive value for first-line treatment efficacy, with combined marker analysis offering superior predictive accuracy compared to individual indicators.
Authors
- Jianying Ning
- Baiqiao Zhang
- Qiaodao Wu
- Qian Hu (ORCID: https://orcid.org/0009-0008-8969-9300)
Institutions
- Shihezi University (CN)
Publication Details
- Journal
- Frontiers in Pediatrics
- Published
- 2025-10-03
- DOI
- https://doi.org/10.3389/fped.2025.1679463
- Primary Topic
- Platelet Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Xinjiang Production and Construction Corps