The mutational landscape and actionable targets of gallbladder cancer: an ancestry-informed and comparative analysis of a Chilean population
This ancestry-informed genomic analysis provides the first comprehensive landscape of Chilean GBC, identifying actionable alterations with potential therapeutic relevance and supporting the development of population-specific precision oncology strategies.
Authors
- Fernanda Morales
- Verónica Sanhueza
- Alejandro Blanco (ORCID: https://orcid.org/0009-0005-3491-6898)
- Katherine Marcelain (ORCID: https://orcid.org/0000-0003-4018-6623)
- Valentina Gárate‐Calderón
- Olga Barajas (ORCID: https://orcid.org/0000-0002-3013-2106)
- Marcela Salgado
- Evelin González
- Arnaldo Marín (ORCID: https://orcid.org/0000-0003-3819-0973)
- Nelson Varela (ORCID: https://orcid.org/0000-0002-5229-3007)
- Gonzalo de Toro (ORCID: https://orcid.org/0000-0003-1022-2865)
- Iván Gallegos
- Gonzalo Sepúlveda-Hermosilla
- Lorena Gutiérrez (ORCID: https://orcid.org/0000-0002-1129-8186)
- Jessica Toro (ORCID: https://orcid.org/0000-0002-7813-1380)
- Loreto Spencer (ORCID: https://orcid.org/0000-0001-7728-015X)
- Erik Morales (ORCID: https://orcid.org/0000-0002-0271-2787)
- Ricardo Armisén (ORCID: https://orcid.org/0000-0003-2567-0521)
- Diego Ampuero
- Justo Lorenzo Bermejo (ORCID: https://orcid.org/0000-0002-6568-5333)
- Camilo Tapia-Valladares
- José Ignacio Erices (ORCID: https://orcid.org/0000-0003-2898-0541)
- Matías Freire
- Mónica Ahumada
- Pablo Báez-Benavides
- Carol Barahona-Ponce
Institutions
- Universidad de Santiago de Chile (CL)
- Universidad del Desarrollo (CL)
- Austral University of Chile (CL)
- Zimmer Biomet (Netherlands) (NL)
- Heidelberg University (DE)
- Catholic University of the Maule (CL)
- Production Development Corporation (CL)
- Hospital Regional de Concepción (CL)
- Hospital San Juan de Dios (CL)
- Hospital Padre Hurtado (CL)
- Hospital Clínico de la Universidad de Chile (CL)
- Instituto Nacional del Cáncer (CL)
- Hospital Regional de Talca (CL)
- University of Chile (CL)
Publication Details
- Journal
- Frontiers in Oncology
- Published
- 2025-10-03
- DOI
- https://doi.org/10.3389/fonc.2025.1658528
- Citations
- 1
- Primary Topic
- Cholangiocarcinoma and Gallbladder Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.01
Funders
- Corporación de Fomento de la Producción
- European Commission
- Universidad de Chile
- Agencia Nacional de Investigación y Desarrollo
- Fondo de Fomento al Desarrollo Científico y Tecnológico
- Fondo de Financiamiento de Centros de Investigación en Áreas Prioritarias