Anti-HLA antibodies bound to monocytes altered antibody-mediated platelet phagocytosis and led to mild thrombocytopenia
These results indicated that anti-MHC-I antibodies preferentially bind to monocytes rather than platelets in whole blood and can be cleared by monocytes <i>via</i> endocytosis. Furthermore, we found that the presence of anti-HLA class I antibodies did not significantly influence platelet clearance induced by anti-αIIbβ3 antibodies. The question of whether these observations can explain the controversial opinions regarding the relative roles of anti-HLA class I and anti-αIIbβ3 antibodies in FNAIT requires further assessment in a murine model of FNAIT.
Authors
- Sentot Santoso (ORCID: https://orcid.org/0000-0001-6943-3945)
- Gregor Bein (ORCID: https://orcid.org/0000-0002-7571-8362)
- Xiuzhang Xu (ORCID: https://orcid.org/0000-0002-1328-6920)
- Hui Ren (ORCID: https://orcid.org/0000-0002-0166-8614)
- Yongshui Fu (ORCID: https://orcid.org/0000-0003-0886-2193)
- Margaret E. Rick
- Yaori Xu (ORCID: https://orcid.org/0000-0002-5498-3554)
- Wenjie Xia (ORCID: https://orcid.org/0000-0002-4681-1947)
- Nelli Baal
- Dawei Chen (ORCID: https://orcid.org/0000-0002-3405-6753)
- Xin Ye (ORCID: https://orcid.org/0000-0003-4043-3700)
- Huaqin Liang
Institutions
- Justus-Liebig-Universität Gießen (DE)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Guangzhou Blood Center (CN)
- Guangzhou First People's Hospital (CN)
- Southern Medical University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-03
- DOI
- https://doi.org/10.3389/fimmu.2025.1652134
- Citations
- 1
- Primary Topic
- Platelet Disorders and Treatments
- Type
- article
- Field-Weighted Citation Impact
- 1.77
Funders
- National Natural Science Foundation of China
- Universität Rostock
- Basic and Applied Basic Research Foundation of Guangdong Province