Propofol-supplemented cardioplegia: A multicenter blinded 3-group randomized trial (Propofol for Myocardial Protection Trial 2: ProMPT2)
Propofol supplementation of warm blood cardioplegia at both the lower and higher concentrations is safe, but there is no evidence to suggest either dose is cardioprotective.
Authors
- Brian T. Fitzgerald
- Chris Rogers (ORCID: https://orcid.org/0000-0002-9624-2615)
- Nnamdi Nwaejike (ORCID: https://orcid.org/0000-0002-0351-7270)
- Ben Gibbison (ORCID: https://orcid.org/0000-0003-3635-6212)
- Rachael Heys (ORCID: https://orcid.org/0000-0002-3957-1287)
- Katherine Joyce (ORCID: https://orcid.org/0000-0002-5539-7178)
- Rachel Maishman (ORCID: https://orcid.org/0000-0002-5052-5951)
- Gianni D. Angelini (ORCID: https://orcid.org/0000-0002-1753-3730)
- M.Saadeh Suleiman (ORCID: https://orcid.org/0000-0001-6080-480X)
- R N Downes (ORCID: https://orcid.org/0000-0002-0476-1718)
- Helena J.M. Smartt (ORCID: https://orcid.org/0000-0001-5285-2262)
- Lucy A. Culliford (ORCID: https://orcid.org/0000-0002-9255-6617)
- Prakash P Punjabi (ORCID: https://orcid.org/0000-0002-6587-1603)
- Samantha E de Jesus (ORCID: https://orcid.org/0009-0000-4220-9169)
Institutions
- Imperial College Healthcare NHS Trust (GB)
- University Hospitals Bristol NHS Foundation Trust (GB)
- At Bristol (GB)
- University of Bristol (GB)
- Manchester University NHS Foundation Trust (GB)
- NIHR Bristol Cardiovascular Biomedical Research Unit (GB)
- Wythenshawe Hospital (GB)
- University Hospitals Bristol and Weston NHS Foundation Trust (GB)
Publication Details
- Journal
- Journal of Thoracic and Cardiovascular Surgery
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1016/j.jtcvs.2025.09.040
- Primary Topic
- Cardiac Ischemia and Reperfusion
- Type
- article
- Field-Weighted Citation Impact
- 0.00