miR-125b-5p and miR-145a-5p modulation drives functional enhancement of Wharton’s Jelly-MSCs derived small extracellular vesicles in response to hypoxia preconditioning
By exploring these comparative functions, the study provides insights into the optimization of sEV-based therapies as a cutting-edge approach in regenerative medicine, and reflects the suitability of WJ-sEV as an ideal acellular therapeutics' candidate for translational regenerative and immunomodulatory applications.
Authors
- Ritu Kulshreshtha (ORCID: https://orcid.org/0000-0003-0488-5048)
- Aastha Singh (ORCID: https://orcid.org/0000-0003-1802-3625)
- Sujata Mohanty
- Yashvi Sharma
- Seema Kashyap
- Sefali Bhakuni
Institutions
- Stem Cell Institute (PA)
- All India Institute of Medical Sciences (IN)
- Indian Institute of Technology Delhi (IN)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1186/s12964-025-02300-1
- Citations
- 2
- Primary Topic
- Extracellular vesicles in disease
- Type
- article
- Field-Weighted Citation Impact
- 1.61