Epigenetic Regulation of Chromosomal Instability by EZH2 Methyltransferase

We elucidate epigenetic regulation of CIN through EZH2-TNKS-CPAP-axis and show that CIN suppression is important for the efficacy of EZH2 inhibition on metastasis. These mechanistic insights are informative for developing CIN-suppressing therapies.

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Publication Details

Journal
Cancer Discovery
Published
2025-10-02
DOI
https://doi.org/10.1158/2159-8290.cd-25-0947
Citations
3
Primary Topic
Epigenetics and DNA Methylation
Type
article
Field-Weighted Citation Impact
2.42
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article

Epigenetic Regulation of Chromosomal Instability by EZH2 Methyltransferase

Cem Meydan, Yang Bai, Henry Withers, Ari Melnick et al.
3 citations
Cancer Discovery
Epigenetics and DNA Methylation
2.42
article

Epigenetic Regulation of Chromosomal Instability by EZH2 Methyltransferase

Cem Meydan, Yang Bai, Henry Withers, Ari Melnick, Lukas E. Dow, Dylan McNally, Bhavneet Bhinder, Ashley M. Laughney, Magdalena Plašilová, Sneha Pramod, Liron Yoffe, Aakanksha R. Kapoor, Samuel F. Bakhoum, Olivier Elemento, Vivek Mittal, Albert S. Agustinus, Christy Hong, Melissa J. Hubisz, Marvel Tranquille, Shira Yomtoubian, Arshdeep Singh
article en
3 citations

Abstract

We elucidate epigenetic regulation of CIN through EZH2-TNKS-CPAP-axis and show that CIN suppression is important for the efficacy of EZH2 inhibition on metastasis. These mechanistic insights are informative for developing CIN-suppressing therapies.

Cancer DiscoveryVol. 16(1)
Dartmouth College (US), Roswell Park Comprehensive Cancer Center (US), Salk Institute for Biological Studies (US), Memorial Sloan Kettering Cancer Center (US), Prince Sattam Bin Abdulaziz University (SA), Cornell University (US), Lander Institute (IL), Weill Cornell Medicine (US)
Openalex Percentile: Top 10%
Epigenetics and DNA Methylation
2.42
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