Native Collagen for Surgical Wound and Scar Prevention—A Six-Case Clinical Series

<b>Background:</b> Excessive scarring remains a frequent complication in plastic surgery, yet standardized preventive strategies are lacking. Type I collagen-based biomaterials may support regenerative processes and improve scar outcomes. <b>Methods:</b> This case series includes six female patients (ages 24-52) undergoing wound management after trauma and procedures including blepharoplasty, abdominoplasty, and revision mammaplasty. Native collagen type I (7% or 15%) was injected along wound margins or into hypertrophic scars at 3-4 week intervals. Outcomes were assessed through patient-reported symptoms and Antera 3D imaging (vascularity, pigmentation, surface topography). <b>Results:</b> Patients reported reduced tightness, pruritus, and scar stiffness after initial sessions. Antera 3D imaging showed decreased vascular and pigment indices, and a reduction in surface elevation over follow-up (up to 14 months). No adverse effects such as atrophy or infection were observed. <b>Conclusions:</b> Native type I collagen was well tolerated and may be a useful adjunct for wound healing and scar modulation following plastic surgery.