The impact of short-term non-steroidal androgen antagonist therapy on PSMA expression and tumor cellularity studied with dynamic [68Ga]Ga-PSMA-11 PET/MR in hormone-sensitive prostate cancer patients, a preliminary longitudinal prospective study
Short-term NSAA induces transient PSMA upregulation in hormone-sensitive PCa lesions despite declining cellularity, which may support its cointegration to PSMA-targeted therapies for this population.
Authors
- Stefan Carlsson (ORCID: https://orcid.org/0000-0002-8489-5029)
- Fredrik Jäderling (ORCID: https://orcid.org/0000-0002-9042-7328)
- Mats Olsson (ORCID: https://orcid.org/0000-0002-4130-1323)
- Olof Jonmarker (ORCID: https://orcid.org/0000-0003-2654-5044)
- Alejandro Sánchez-Crespo (ORCID: https://orcid.org/0000-0002-5964-0024)
- Rimma Axelsson (ORCID: https://orcid.org/0000-0003-4702-1020)
- Chunde Li (ORCID: https://orcid.org/0000-0003-4331-079X)
Institutions
- Karolinska University Hospital (SE)
- Karolinska Institutet (SE)
- Stockholm South General Hospital (SE)
- Saint Göran Hospital (SE)
Publication Details
- Journal
- EJNMMI Research
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1186/s13550-025-01328-1
- Primary Topic
- Prostate Cancer Treatment and Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Karolinska Institutet