Spatial atlasing of N-glycosylation in healthy control and clear cell renal cell carcinoma tissues linked with immune checkpoint inhibition response by MALDI mass spectrometry imaging
This study represents an expanded spatial characterization of the normal renal N-glycome. Additionally, the N-glycomes of ccRCC tissues were compared relative to normal tissues, and in context of response to ICI. Candidate glycan-based biomarkers could eventually be developed for clinical translational applications at baseline to predictively identify responders and non-responders to ICI.
Authors
- Viktor Grünwald (ORCID: https://orcid.org/0000-0003-2083-7687)
- Lyndsay E.A. Young (ORCID: https://orcid.org/0000-0002-6873-5674)
- Anand S. Mehta (ORCID: https://orcid.org/0000-0002-9846-9389)
- Philipp Ivanyi (ORCID: https://orcid.org/0000-0002-2862-7302)
- Peggi M. Angel (ORCID: https://orcid.org/0000-0002-4436-555X)
- Colin T. McDowell (ORCID: https://orcid.org/0000-0001-8739-277X)
- Christopher Darr (ORCID: https://orcid.org/0000-0003-2532-8398)
- Richard Drake
- Jan Hinrich Bräsen (ORCID: https://orcid.org/0000-0002-2863-3067)
- Nikolaos Vasileiadis (ORCID: https://orcid.org/0000-0002-6245-7220)
- Jessica Schmitz (ORCID: https://orcid.org/0000-0001-9843-7339)
- Grace Grimsley
- Caroline G. Kittrell (ORCID: https://orcid.org/0000-0002-2506-919X)
Institutions
- Medical University of South Carolina (US)
- Medizinische Hochschule Hannover (DE)
- Essen University Hospital (DE)
Publication Details
- Journal
- Analytica Chimica Acta
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1016/j.aca.2025.344724
- Primary Topic
- Glycosylation and Glycoproteins Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00