NDM-1 plasmid clustering reflects clonal transmission of Klebsiella pneumoniae ST147 in four hospitals in Berlin, Germany
Both plasmid-level analysis and cgMLST yielded congruent results, effectively ruling out the possibility of multi-site, plasmid-mediated NDM-1 transmission. The detection of a globally disseminated NDM-1 plasmid within one of the clonal clusters highlights its potential role in the spread of resistance during the recent surge of NDM-1 carrying KLPN isolates in Germany.
Authors
- Luisa A. Denkel (ORCID: https://orcid.org/0000-0003-4005-1315)
- Friederike Maechler (ORCID: https://orcid.org/0000-0002-9554-3133)
- Anna Weber (ORCID: https://orcid.org/0000-0001-9294-7987)
- Christine Geffers (ORCID: https://orcid.org/0000-0003-3047-6416)
- Axel Kola (ORCID: https://orcid.org/0000-0003-4333-5663)
Institutions
- Berlin Institute of Health at Charité - Universitätsmedizin Berlin (DE)
- Charité - Universitätsmedizin Berlin (DE)
Publication Details
- Journal
- Antimicrobial Resistance and Infection Control
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1186/s13756-025-01639-x
- Primary Topic
- Antibiotic Resistance in Bacteria
- Type
- article
- Field-Weighted Citation Impact
- 0.00