Missed colorectal cancer diagnosis by screening colonoscopy based on the PLCO cancer screening trial
Colonoscopy missed a relatively high proportion of CRC, mainly in the proximal colon (especially in the hepatic flexure and cecum of the colon). Recent developments in non-invasive screening technologies, such as stool DNA testing and liquid biopsy, may help address the limitations of colonoscopy. Combining these approaches with traditional endoscopy could enhance overall detection accuracy and reduce the rate of missed colorectal cancer.
Authors
- Tongzhou Liang (ORCID: https://orcid.org/0000-0001-5920-5412)
- Wencheng Tan
- Huan Xiong (ORCID: https://orcid.org/0000-0002-7191-3259)
- Yuying Liu (ORCID: https://orcid.org/0000-0002-7105-5311)
- Chuanbo Xie (ORCID: https://orcid.org/0000-0001-6228-5855)
- Liang He (ORCID: https://orcid.org/0000-0002-5279-0097)
- Xiaofang Qiu
- Jianjun Li (ORCID: https://orcid.org/0000-0002-6034-2411)
- Ying Li (ORCID: https://orcid.org/0000-0003-3149-8457)
- Baiyu Zhong
- Yuhong Wang (ORCID: https://orcid.org/0000-0002-6876-3114)
Institutions
- Sun Yat-sen University (CN)
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Peking University Shenzhen Hospital (CN)
- The First Affiliated Hospital, Sun Yat-sen University (CN)
- Sun Yat-sen University Cancer Center (CN)
Publication Details
- Journal
- International Journal of Colorectal Disease
- Published
- 2025-10-03
- DOI
- https://doi.org/10.1007/s00384-025-04952-4
- Citations
- 1
- Primary Topic
- Colorectal Cancer Screening and Detection
- Type
- article
- Field-Weighted Citation Impact
- 1.05