Study of the interferon profile in children with bronchial asthma

Introduction. Bronchial asthma in children is an urgent medical problem. Currently, there are separate clusters of BA variants and various phenotypes. ARVI is the most frequent trigger of BA exacerbations, which makes the study of interferon status relevant. Methods. A study of IFN-α and IFN-γ in the blood serum of children with AIBA (n = 60) and VIBA (n = 10). Results. An increase in IFN-γ was found in AIBA by 1.9 times and in VIBA by 1.7 times. An increase in IFN-α was observed in both AIBA (4.7 times, 2.95 ± 0.73 pg/ml) and VIBA (9.9 tim es, 6.24 ± 1.32 pg/ml). A decrease in IFN-γ in the blood serum was observed in moderate AIBA (1.23 ± 1.59 pg/ml) and severe AIBA (0.76 ± 0.64 pg/ml). Conclusion. Decreased IFN-γ content is an important factor in the severe course of AIB. As an additional marker for the diagnosis of BA phenotype, the use of IFN-α / IFN-γ ratio is proposed.