Ciclesonide shows a lung-protective effect in neonatal hyperoxia-exposed rats
Postnatal ciclesonide administration preserved lung function and structure and prevented right ventricular hypertrophy in a hyperoxic BPD-like model. These findings suggest that postnatal ciclesonide may be an alternative to existing corticosteroids for the treatment of BPD. However, long-term studies are required to validate these findings.
Authors
- Lara Olazar
- Carmen Rey‐Santano (ORCID: https://orcid.org/0000-0002-3855-3327)
- Victoria Mielgo (ORCID: https://orcid.org/0000-0001-6386-6133)
- Begoña Loureiro (ORCID: https://orcid.org/0000-0001-6065-1364)
- Miguel Angel Gomez‐Solaetxe (ORCID: https://orcid.org/0000-0003-1509-046X)
Institutions
- University of the Basque Country (ES)
- BioCruces Health research Institute (ES)
Publication Details
- Journal
- Clinical and Experimental Pediatrics
- Published
- 2025-10-02
- DOI
- https://doi.org/10.3345/cep.2025.01137
- Primary Topic
- Neonatal Respiratory Health Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Instituto de Salud Carlos III
- European Regional Development Fund