Integrative genetic and multi-omics analysis reveals the interleukin-6 receptor’s role in recurrent spontaneous abortion
IL6R upregulation is mechanistically implicated in the pathogenesis of RSA, establishing it as a validated causal biomarker and a potentially actionable therapeutic target. This study not only highlights the role of IL6R in RSA but also supports its development into a therapeutic strategy with a comprehensive safety profile.
Authors
- Ge Song (ORCID: https://orcid.org/0009-0000-4535-2112)
- Han Lin (ORCID: https://orcid.org/0000-0003-1663-5468)
- Qiwang Lin (ORCID: https://orcid.org/0000-0003-1636-0257)
- Mingzhu Cao (ORCID: https://orcid.org/0000-0003-1329-4215)
- Zhongjia Gu
- Mengchang Xu (ORCID: https://orcid.org/0000-0002-2590-9814)
- Xin Li (ORCID: https://orcid.org/0000-0002-9466-2659)
- Hongyan Li (ORCID: https://orcid.org/0000-0002-5437-9779)
- Yue Lin
- Lili Du
- Jianqiao Liu (ORCID: https://orcid.org/0000-0002-4061-3333)
- Junmin Zhong (ORCID: https://orcid.org/0009-0000-1728-620X)
- Weixu Ma
Institutions
- Changsha Medical University (CN)
- Third Affiliated Hospital of Guangzhou Medical University (CN)
- Key Laboratory of Guangdong Province (CN)
- First Affiliated Hospital of Guangzhou Medical University (CN)
- Foshan Maternity and Child Health Care Hospital (CN)
- Guangzhou Women and Children Medical Center (CN)
- Institut de Médecine de la Reproduction (FR)
- First Affiliated Hospital of Jinan University (CN)
- Guangzhou Medical University (CN)
Publication Details
- Journal
- Frontiers in Immunology
- Published
- 2025-10-02
- DOI
- https://doi.org/10.3389/fimmu.2025.1659251
- Citations
- 4
- Primary Topic
- Reproductive System and Pregnancy
- Type
- article
- Field-Weighted Citation Impact
- 3.19