SADI-S and SG surgeries induce distinct bile acid profiles linked to improved glucose metabolism via microbiota interactions
SADI-S and SG induce distinct, surgery-specific BA remodeling that is significantly associated with metabolic improvements in T2D. The robust correlations between specific BA species and metabolic parameters underscore their potential as mediators and therapeutic targets. SADI-S promotes a more extensive and beneficial BA profile, aligning with its superior metabolic efficacy.
Authors
- Zhubin Shen
- Subo Ma
- Lifu Hu
- Tao Jiang (ORCID: https://orcid.org/0000-0002-0968-0300)
- C. H. Fang (ORCID: https://orcid.org/0000-0003-2474-906X)
- Lun Wang (ORCID: https://orcid.org/0000-0002-0232-9294)
- Zheng Zhang (ORCID: https://orcid.org/0000-0002-6954-8790)
- Zhiqiang Wei (ORCID: https://orcid.org/0000-0002-6965-0162)
Institutions
- Union Hospital (HK)
- Zunyi Medical University (CN)
- Jilin University (CN)
- Union Hospital (CN)
- First Affiliated Hospital Zhejiang University (CN)
- Zhejiang University (CN)
Publication Details
- Journal
- Frontiers in Microbiology
- Published
- 2025-10-02
- DOI
- https://doi.org/10.3389/fmicb.2025.1579149
- Primary Topic
- Bariatric Surgery and Outcomes
- Type
- article
- Field-Weighted Citation Impact
- 0.00