The miR-34/449 clusters regulate the differentiation of ciliated cells in the oviduct via the Wnt/β-catenin signaling pathway
In summary, we discovered that ablation of miR-34/449 led to hyperactivation of the Wnt/β-catenin signaling pathway, which resulted in the differentiation impairment of ciliated cells, thus resulting in infertility in the mice. This study revealed a novel mechanism describing how miR-34/449 affects oviductal ciliated cell differentiation and oviductal epithelial homeostasis through the Wnt/β-catenin signaling pathway and finally affects fertility.
Authors
- Furong Bai (ORCID: https://orcid.org/0000-0002-5312-5021)
- Qiqian Wu
- Yujie Wu (ORCID: https://orcid.org/0000-0001-7479-1544)
- Yanqin Hu (ORCID: https://orcid.org/0000-0002-6156-8471)
- Jingwen Wu (ORCID: https://orcid.org/0000-0003-0939-511X)
- Yunxia Zhang (ORCID: https://orcid.org/0000-0002-5312-6411)
Institutions
- Shanghai University (CN)
- Shanghai Jiao Tong University (CN)
- Shanghai First People's Hospital (CN)
Publication Details
- Journal
- Cell & Bioscience
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1186/s13578-025-01468-w
- Primary Topic
- Renal and related cancers
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Natural Science Foundation of Shanghai
- Shanghai Municipal Health Commission
- National Natural Science Foundation of China
- Shanghai Jiao Tong University