Berberine ameliorates acute hyperglycemia and hypoinsulinemia induced by ketamine/xylazine in rats: role of alpha2 adrenergic receptors, oxidative stress and inflammatory suppressing mechanisms
Overall, berberine helps counteract K/X-induced hyperglycemia and hypoinsulinemia. Anti-hyperglycemic synergy between berberine and yohimbine suggests that berberine works partly by blocking α2 adrenergic receptors. In addition, oxidative stress and pro-inlammatory mediators reduction and anti-oxidative activity elevation might be involved in these metabolic effects of berberine.
Authors
- Rusul Abdulhameed Kadhim
- Esmaeal Tamaddonfard (ORCID: https://orcid.org/0000-0001-8240-5885)
- Mehdi Imani (ORCID: https://orcid.org/0000-0002-9990-4389)
- Amir Erfanparast (ORCID: https://orcid.org/0000-0003-2526-2253)
- Davoud Amirkashani (ORCID: https://orcid.org/0000-0002-0838-3005)
Institutions
- Iran University of Medical Sciences (IR)
- Urmia University (IR)
Publication Details
- Journal
- BMC Veterinary Research
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1186/s12917-025-05017-y
- Citations
- 1
- Primary Topic
- Berberine and alkaloids research
- Type
- article
- Field-Weighted Citation Impact
- 1.39
Funders
- Urmia University