Synergistic potential of Berberine and Wogonin improved adipose inflammation and insulin resistance associated with obesity through HIF-α axis
The synergistic constituents of Coptidis Rhizoma-Scutellariae Radix, namely BBR and WOG, synergistically alleviate IR associated with obesity by inhibiting HIF-1α and activating HIF-2α, respectively. This study elucidates the mechanistic basis of herbal combination therapy for metabolic disorders and provides a foundation for developing novel synergistic therapeutics against obesity-related IR.
Authors
- Hua Yang (ORCID: https://orcid.org/0000-0002-4876-4072)
- Yinyue Xu
- Zu‐Guo Zheng (ORCID: https://orcid.org/0000-0003-3991-1728)
- Xiaoyu Zhang (ORCID: https://orcid.org/0000-0001-7528-4405)
- Ping Li (ORCID: https://orcid.org/0000-0002-8515-7773)
- Zheng‐Yi Zhou (ORCID: https://orcid.org/0000-0001-9014-8479)
- Mingsu Wang
Institutions
- China Pharmaceutical University (CN)
Publication Details
- Journal
- Chinese Medicine
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1186/s13020-025-01223-w
- Citations
- 5
- Primary Topic
- Flavonoids in Medical Research
- Type
- article
- Field-Weighted Citation Impact
- 6.97
Funders
- National Natural Science Foundation of China
- Government of Jiangsu Province
- National Science and Technology Major Project