EFFECTS OF POLYPHENOLIC COMPOUNDS ON BIOCHEMICAL PROFILE AND RENAL MORPHOLOGY IN THE CONTEXT OF EXPERIMENTAL METABOLIC SYNDROME

Objective: To study the effect of polyphenolic compounds on biochemical profile and renal morphology in the context of experimental metabolic syndrome (MetS). Methods: An experimental study was conducted involving 50 Wistar rats, utilizing a high fructose diet to simulate metabolic syndrome (MetS). The animals were grouped into groups of 10 based on the treatments they received, which included Edarbi (azilsartan) and polyphenol‐rich extracts from grape cane and seeds. There was also a comparison group consisting of rats with MetS that did not receive any treatment, as well as a control group of healthy intact animals. Biochemical and morphological methods were employed to evaluate the effectiveness of the various therapeutic strategies.Results: Polyphenol‐rich extracts derived from grape cane and seeds, along with angiotensin II type 1 receptor blockers, such as Edarbi (azilsartan), have demonstrated a beneficial effect in preventing the onset of MetS. Conclusion: The results of the study suggest that polyphenol‐rich extracts derived from grape seeds and cane may offer nephroprotective benefits in the context of MetS. Therefore, the study recommends these extracts for clinical trials as part of a comprehensive treatment approach for metabolic nephropathy and other kidney-related diseases linked to metabolic disorders. Keywords: Metabolic syndrome, nephropathy, polyphenols, resveratrol.