INTRA-OPERATIVE AWARENESS WITH THE USE OF INFUSION DEXMEDETOMIDINE AND INFUSION PROPOFOL IN PATIENTS UNDERGOING CORONARY ARTERY BYPASS GRAFTING

Background: Awareness under anaesthesia is defined as the patient's memory of intraoperative events while under general anaesthesia. Although uncommon, it is a well-known anaesthesia complication. Despite the improvement in anesthesia technique and anesthetics, risk of awareness during anesthesia is high. Objectives: To assess the intra-operative awareness of patients with the use of infusion dexmedetomidine and infusion propofol in patients undergoing coronary artery bypass grafting. Method: This cross-sectional study was conducted on 300 patients and their medical records were assessed to note the intraoperative vitals and anesthesia details. Then patients were interviewed through Brice questionnaire. On the basis of responses, awareness during anesthesia was noted. All the data was recorded in proforma and analyzed in SPSS v. 25. Results: Overall, the mean patient age was 59.28 ± 8.68 years. Only 2 (0.67%) of 300 patients revealed awareness under anesthesia. 1 young patient (50%) and 1 geriatric patient (50%, p = 0.924) experienced awareness during anesthesia, compared to 2 females (100%) and 0% (0.000) of men. Patients with overweight and obesity were more aware than those with normal or severe obesity (p = 0.447). Anesthesia duration did not significantly affect awareness during anesthesia, with 100% of patients experiencing awareness throughout 240 min (p = 0.676). Operative and intubation time did not affect awareness (p >0.05). Two (100%) individuals with pre-operative MAP 91-120 mmHg had awareness during anesthesia, with significant impact from heart rate and ejection fraction (p <0.05) among 300 patients. Conclusion: We conclude that with use of Dexmedetomidine and Propofol infusion, the risk of awareness during anesthesia is very low (0.67%). Key words: intra-operative awareness, infusion, dexmedetomidine, propofol, coronary artery bypass grafting