Laser-activated nanoparticles rewire tumor microenvironment enhancing PD-1 blockade and T cell response in cholangiocarcinoma

Our findings emphasize the therapeutic potential of combining nanotechnology and immunotherapy to reshape the TME and overcome immunotherapy resistance in fibrotic tumors, such as CCA. Targeting both ECM and immune checkpoints has emerged as a promising and versatile strategy to enhance the efficacy of immunotherapy against desmoplastic cancers.

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Institutions

Publication Details

Journal
Hepatology
Published
2025-10-02
DOI
https://doi.org/10.1097/hep.0000000000001545
Citations
7
Primary Topic
Cholangiocarcinoma and Gallbladder Cancer Studies
Type
article
Field-Weighted Citation Impact
14.04
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article

Laser-activated nanoparticles rewire tumor microenvironment enhancing PD-1 blockade and T cell response in cholangiocarcinoma

Jonathan Pol, Thomas Guilbert, Mirko Minini, Rana Bazzi et al.
7 citations
Hepatology
Cholangiocarcinoma and Gallbladder Cancer Studies
14.04
article

Laser-activated nanoparticles rewire tumor microenvironment enhancing PD-1 blockade and T cell response in cholangiocarcinoma

Jonathan Pol, Thomas Guilbert, Mirko Minini, Rana Bazzi, Giulio Avveduto, Christophe Klein, Julie Lesieur, Bouchra Lekbaby, Jérémy Augustin, Emmanuel Donnadieu, Stéphane Roux, Sonia Becharef, Gilles Renault, Florence Gazeau, Ida Chiara Guerrera, Laura Fouassier, Sara Ceccacci, Alice Machado, Marie Meunier--Thaens, Maria Perez-Lazon
article en
7 citations

Abstract

Our findings emphasize the therapeutic potential of combining nanotechnology and immunotherapy to reshape the TME and overcome immunotherapy resistance in fibrotic tumors, such as CCA. Targeting both ECM and immune checkpoints has emerged as a promising and versatile strategy to enhance the efficacy of immunotherapy against desmoplastic cancers.

Hepatology
Université Paris-Sud (FR), Centre National de la Recherche Scientifique (FR), Inserm (FR), Université Paris-Est Créteil (FR), Université Paris Cité (FR), Université Paris-Saclay (FR), Institut Gustave Roussy (FR), Sorbonne Université (FR), Sorbonne Paris Cité (FR), Centre de Recherche des Cordeliers (FR), La Ligue Contre le Cancer (FR), Assistance Publique – Hôpitaux de Paris (FR), Laboratoire Chrono-Environnement (FR), Centre de Recherche Saint-Antoine (FR), Institut Cochin (FR), Institut Mondor de Recherche Biomédicale (FR), Structure fédérative de recherche Necker (FR), Université Marie et Louis Pasteur (FR), Université de Franche-Comté (FR)
Openalex Percentile: Top 1%
Cholangiocarcinoma and Gallbladder Cancer Studies
14.04
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