Age-Related Differences in Speech Production and Resting State Functional Network Dynamics

Age-related declines in cognitive function are often accompanied by changes in brain activity and network organization. This study investigated the relationship between resting state brain activity and age-related differences in speech production. We hypothesized that older adults would exhibit altered functional connectivity and activation intensity, correlating with reduced speech quality. Resting state functional MRI data were collected and a composite measure of speech complexity and fluency was calculated from younger and older adults. Results revealed significantly worse speech performance in older adults, accompanied by less segregated whole-brain networks, reduced amplitude of low-frequency fluctuations, and more heterogeneous brain states. Univariate regression analyses indicated stronger brain-behavior relationships in younger adults, while multivariate regression analyses revealed that age-related differences in resting state brain state patterns critically relate to speech production differences. Notably, the language network remained relatively stable with age, whereas whole-brain status became very important for speech performance in older adults. These findings suggest that resting state brain activity, particularly whole brain network characteristics, may serve as a stable biomarker of age-related changes in speech production.