Epigenetic and Transcriptional Programs Define Osteosarcoma Subtypes and Establish Targetable Vulnerabilities
This study identifies two distinct cellular states in osteosarcoma, driven by specific transcription factor circuitries linked to normal bone development. These epigenetically defined states demonstrate differential drug responses, are identifiable in patient samples, and are correlated with survival.
Authors
- Alex G. Lee (ORCID: https://orcid.org/0000-0003-0107-5920)
- E. Alejandro Sweet‐Cordero (ORCID: https://orcid.org/0000-0002-9787-9351)
- Andrew Clugston (ORCID: https://orcid.org/0000-0002-8521-9452)
- Eunice López-Fuentes (ORCID: https://orcid.org/0000-0001-6794-5883)
- Leanne C. Sayles (ORCID: https://orcid.org/0000-0003-3963-6412)
- Marcus R. Breese (ORCID: https://orcid.org/0000-0002-6870-0228)
- María V. Pons Ventura (ORCID: https://orcid.org/0009-0003-9516-2052)
- Stanley G. Leung (ORCID: https://orcid.org/0000-0001-9470-8760)
- N. Sörensen
- Truc Dinh (ORCID: https://orcid.org/0000-0002-8985-0225)
Institutions
- University of California, San Francisco (US)
- Indiana University School of Medicine
- Indiana University – Purdue University Indianapolis (US)
Publication Details
- Journal
- Cancer Discovery
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1158/2159-8290.cd-25-0237
- Citations
- 3
- Primary Topic
- Sarcoma Diagnosis and Treatment
- Type
- article
- Field-Weighted Citation Impact
- 4.56