Data-driven risk algorithms from primary care for early dementia detection and prevention trial enrichment
Background: Early identification of individuals at risk of dementia is essential for effective prevention and timely intervention. Existing risk scores rely heavily on age, which limits their discriminative power at clinically relevant thresholds such as 65 years, when preventive strategies are most impactful.
Authors
- Manon Ansart (ORCID: https://orcid.org/0000-0002-0703-2908)
- Mika Kivimaki B (ORCID: https://orcid.org/0000-0002-4699-5627)
- Karim Zaidi
- Thomas Nédelec (ORCID: https://orcid.org/0000-0002-9310-2879)
- Octave Guinebretiere (ORCID: https://orcid.org/0009-0005-1876-2948)
- Pyry N. Sipilä (ORCID: https://orcid.org/0000-0003-4886-8151)
- Stanley Durrleman (ORCID: https://orcid.org/0000-0002-9450-6920)
- Fen Yang (ORCID: https://orcid.org/0000-0001-7078-3635)
- Yulin Hswen
- Fang Fang (ORCID: https://orcid.org/0000-0002-1805-2031)
- Wei Dang (ORCID: https://orcid.org/0000-0002-8356-1086)
- Charlotte Montaud
Institutions
- Centre National de la Recherche Scientifique (FR)
- University of Helsinki (FI)
- Inserm (FR)
- Université de Bourgogne (FR)
- University of California, San Francisco (US)
- Harvard University Press (US)
- Karolinska Institutet (SE)
- Sorbonne Université (FR)
- Université Bourgogne Franche-Comté (FR)
- Centre d'Immunologie et des Maladies Infectieuses (FR)
- Laboratoire de Biologie et Pharmacologie Appliquée (FR)
- Criteo (France) (FR)
- University College London (GB)
Publication Details
- Journal
- Communications Medicine
- Published
- 2026-08-24
- DOI
- https://doi.org/10.1038/s43856-026-01850-w
- Primary Topic
- Dementia and Cognitive Impairment Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Suomen Lääketieteen Säätiö
- Wellcome Trust
- EU Joint Programme – Neurodegenerative Disease Research
- Agence Nationale de la Recherche
- Emil Aaltosen Säätiö
- National Institutes of Health
- Medical Research Council
- National Health and Medical Research Council