Integrated Computational and Experimental Discovery of a Promising Xanthine Derivative with Anticancer Potential Targeting EGFR
T-1-PA is a promising semisynthetic compound with selective antiproliferative activity mediated via EGFR inhibition. These findings encourage further preclinical investigation of T-1-PA as a novel candidate for EGFR-targeted cancer therapy.
Authors
- Ibrahim H. Eissa (ORCID: https://orcid.org/0000-0002-6955-2263)
- Hanan Al-Ghulikah (ORCID: https://orcid.org/0000-0002-3253-9698)
- Ahmed Soliman Doghish (ORCID: https://orcid.org/0000-0002-0136-7096)
- Reda G. Yousef (ORCID: https://orcid.org/0000-0003-3709-1930)
- Hazem Elkady (ORCID: https://orcid.org/0000-0003-0893-6703)
- Omar Soliman (ORCID: https://orcid.org/0000-0003-0488-7385)
- Eslam B. Elkaeed (ORCID: https://orcid.org/0000-0002-2546-8035)
- Dalal Z. Husein (ORCID: https://orcid.org/0000-0001-7552-0914)
- Ahmed M. Metwaly (ORCID: https://orcid.org/0000-0001-8566-1980)
- Ibrahim M. Ibrahim (ORCID: https://orcid.org/0000-0002-9221-1272)
Institutions
- Princess Nourah bint Abdulrahman University (SA)
- Alfaisal University (SA)
- Cairo University (EG)
- Al-Azhar University (EG)
- South Valley University (EG)
- Badr University in Cairo (EG)
- New Valley University
- Almaarefa University
- Alexandria University (EG)
Publication Details
- Journal
- Current Cancer Drug Targets
- Published
- 2025-10-01
- DOI
- https://doi.org/10.2174/0115680096363027250731042338
- Primary Topic
- Synthesis and biological activity
- Type
- article
- Field-Weighted Citation Impact
- 0.00