Inflammatory-immune crosstalk in aneurysmal subarachnoid hemorrhage: bidirectional Mendelian randomization and causal mediation evidence
We establish a novel immune-inflammatory axis wherein CD4+ T cell surface signatures confer protection against intracranial aneurysm rupture partially through CX3CL1 downregulation, while interleukin-7 independently promotes rupture. These findings reveal actionable targets for risk stratification and immunomodulatory interventions.
Authors
- Yi Shen (ORCID: https://orcid.org/0000-0002-3198-1927)
- Jinning Song (ORCID: https://orcid.org/0000-0002-0620-8983)
- Yunfei Zhou (ORCID: https://orcid.org/0000-0002-8436-5511)
- Longxiao Zhang (ORCID: https://orcid.org/0000-0003-2966-0240)
- Liangchao Jiang (ORCID: https://orcid.org/0000-0002-6511-2332)
- Zhongbo Yang (ORCID: https://orcid.org/0000-0002-7365-0819)
- Xinyang Yan (ORCID: https://orcid.org/0009-0004-0919-8698)
- Jiachen Wang (ORCID: https://orcid.org/0000-0001-5526-6816)
- Zheng Zhang (ORCID: https://orcid.org/0000-0003-3127-8710)
- Jiaxi Li (ORCID: https://orcid.org/0000-0002-2007-6366)
Institutions
- Xi'an Honghui Hospital (CN)
- Xenobe Research Institute (US)
- Precision for Medicine (United States) (US)
- First Affiliated Hospital of Xi'an Jiaotong University (CN)
- Xi'an Jiaotong University (CN)
Publication Details
- Journal
- Neurological Research
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1080/01616412.2025.2568031
- Primary Topic
- Connective tissue disorders research
- Type
- article
- Field-Weighted Citation Impact
- 0.00