Fast and furious: mapping epithelial cellular turnover into intestinal transcriptomic atlases
Understanding temporal dynamics in tissue biology is key to linking transcriptomic snapshots to physiological function. Barkai et al. propose a turnover score derived from gene expression of shed epithelial cells, transforming static maps into dynamic representations of cell renewal across the intestinal tract.
Authors
- Lorenz Adlung (ORCID: https://orcid.org/0000-0002-0971-2309)
- Christoph Kilian (ORCID: https://orcid.org/0000-0003-0933-6152)
Institutions
- Universität Hamburg (DE)
- MSH Medical School Hamburg – University of Applied Sciences and Medical University (DE)
- University Medical Center Hamburg-Eppendorf (DE)
- University Cancer Center Hamburg (DE)
- Hamburg Institute for Therapy Research (DE)
Publication Details
- Journal
- Molecular Systems Biology
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1038/s44320-025-00156-8
- Primary Topic
- Single-cell and spatial transcriptomics
- Type
- article
- Field-Weighted Citation Impact
- 0.00