The Definition of Cure in Colon Cancer
In this pooled analysis of phase 3 randomized clinical trials, a recurrence rate less than 0.5% occurred after 6 years from surgery, supporting a practical definition of cure. Recognizing this milestone may improve patient communication, guide follow-up duration, and reduce unnecessary long-term surveillance.
Authors
- Rachel Kerr (ORCID: https://orcid.org/0000-0002-7240-3269)
- Alberto Sobrero (ORCID: https://orcid.org/0000-0001-7764-673X)
- Steven R. Alberts (ORCID: https://orcid.org/0000-0002-5835-4122)
- Thomas J. George (ORCID: https://orcid.org/0000-0002-6249-9180)
- Chris Twelves (ORCID: https://orcid.org/0000-0002-1849-7153)
- Alessandro Pastorino (ORCID: https://orcid.org/0000-0003-4207-3665)
- Julien Taı̈eb (ORCID: https://orcid.org/0000-0002-9955-4753)
- Alberto Puccini (ORCID: https://orcid.org/0000-0002-2492-4043)
- Andrea Harkin (ORCID: https://orcid.org/0000-0002-8831-7381)
- Leonard B. Saltz (ORCID: https://orcid.org/0000-0001-8353-4670)
- Valentino Martelli (ORCID: https://orcid.org/0000-0002-4541-5299)
- Qian Shi (ORCID: https://orcid.org/0000-0002-4640-8832)
- Sara Lonardi (ORCID: https://orcid.org/0000-0002-7593-8138)
- Levi Pederson (ORCID: https://orcid.org/0000-0001-5902-8882)
- Aimery de Gramont (ORCID: https://orcid.org/0000-0001-7940-9877)
- Timothy Iveson (ORCID: https://orcid.org/0000-0002-4681-2712)
- Norman Wolmark (ORCID: https://orcid.org/0000-0001-7156-1110)
- Greg Yothers (ORCID: https://orcid.org/0000-0002-7965-7333)
- Heshan Liu (ORCID: https://orcid.org/0000-0002-9636-8509)
- Takayuki Yoshino (ORCID: https://orcid.org/0000-0002-0489-4756)
- Thierry André (ORCID: https://orcid.org/0000-0002-5103-7095)
- Ioannis Souglakos
- Roberto Labianca (ORCID: https://orcid.org/0000-0001-7149-822X)
- Hans‐Joachim Schmoll (ORCID: https://orcid.org/0000-0001-8705-0593)
- Richard M. Goldberg (ORCID: https://orcid.org/0000-0003-3713-6895)
Institutions
- West Virginia University (US)
- University of Leeds (GB)
- Mayo Clinic (US)
- Memorial Sloan Kettering Cancer Center (US)
- Humanitas University (IT)
- University of Pittsburgh (US)
- Université Paris Cité (FR)
- Leeds Teaching Hospitals NHS Trust (GB)
- University of Florida Health (US)
- Sorbonne Université (FR)
- Sorbonne Paris Cité (FR)
- Assistance Publique – Hôpitaux de Paris (FR)
- Hôpital Européen Georges-Pompidou (FR)
- Ospedale Papa Giovanni XXIII (IT)
- Istituto Oncologico Veneto (IT)
- UPMC Hillman Cancer Center (US)
- Centre de Recherche Saint-Antoine (FR)
- Institut Hospitalier Franco Britannique (FR)
- University Hospital of Heraklion (GR)
- National Cancer Center Hospital East (JP)
- Ospedale Policlinico San Martino (IT)
- Mayo Clinic in Florida (US)
- University Hospital in Halle (DE)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Cancer Research UK Oxford Centre (GB)
- NSABP Foundation (US)
- IRCCS Humanitas Research Hospital (IT)
- University of Southampton (GB)
- UF Health Cancer Center
- Martin Luther University Halle-Wittenberg (DE)
- University of Glasgow (GB)
Publication Details
- Journal
- JAMA Oncology
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1001/jamaoncol.2025.3760
- Citations
- 2
- Primary Topic
- Colorectal Cancer Treatments and Studies
- Type
- article
- Field-Weighted Citation Impact
- 2.09