Traumatic Brain Injury and Risk of Amyotrophic Lateral Sclerosis
In this retrospective cohort study of 342 760 adults, an association between TBI and subsequent risk of ALS was identified. However, this association was confined to the 2 years immediately following injury. As such, the association between TBI and higher ALS risk may indicate reverse causality, with TBI in some individuals perhaps reflecting a consequence of early, subclinical ALS.
Authors
- Emma Russell (ORCID: https://orcid.org/0000-0002-5320-5910)
- Jill P. Pell (ORCID: https://orcid.org/0000-0002-8898-7035)
- Xingxing Zhu (ORCID: https://orcid.org/0000-0002-5453-1769)
- Daniel Mackay (ORCID: https://orcid.org/0000-0001-5381-7098)
- Laura M. Lyall (ORCID: https://orcid.org/0000-0001-7216-1434)
- Frederick K. Ho (ORCID: https://orcid.org/0000-0001-7190-9025)
- William J. Stewart (ORCID: https://orcid.org/0000-0002-4900-5465)
Institutions
- Queen Elizabeth University Hospital (GB)
- University of Glasgow (GB)
Publication Details
- Journal
- JAMA Network Open
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1001/jamanetworkopen.2025.35119
- Primary Topic
- Amyotrophic Lateral Sclerosis Research
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- U.S. Department of Defense
- MND Scotland
- University of Glasgow
- National Institutes of Health
- Medical Research Council