Partial vs Whole Laryngeal Radiotherapy for Clinical Stage T1-2N0M0/Tis Laryngeal Carcinoma
This cohort study found that there were no clinically important differences observed in locoregional control between PLRT and WLRT; however, PLRT may be associated with lower rates of acute toxic effects compared to WLRT. Wide confidence intervals across all end points indicated substantial uncertainty regarding comparative effectiveness. The shorter median follow-up time in the PLRT group limited evaluation of late toxic effects and long-term tumor control outcomes; together with the lack of adjustment for confounding factors, this study underscores the need for further evaluation of PLRT.
Authors
- Sean Matthew McBride (ORCID: https://orcid.org/0000-0002-9676-1669)
- Daphna Y. Gelblum (ORCID: https://orcid.org/0000-0001-7211-6246)
- Snehal G. Patel (ORCID: https://orcid.org/0000-0003-1455-463X)
- Jennifer R. Cracchiolo (ORCID: https://orcid.org/0000-0003-4496-906X)
- Kaveh Zakeri (ORCID: https://orcid.org/0000-0003-3921-480X)
- Nadeem Riaz (ORCID: https://orcid.org/0000-0001-9873-5862)
- Yao Yu (ORCID: https://orcid.org/0000-0002-2814-4482)
- Nancy Y. Lee (ORCID: https://orcid.org/0000-0003-3044-9522)
- Edward Christopher Dee (ORCID: https://orcid.org/0000-0001-6119-0889)
- Teeradon Treechairusame (ORCID: https://orcid.org/0000-0002-2731-9500)
- Marc A. Cohen (ORCID: https://orcid.org/0000-0002-6104-7967)
- Richard J. Wong (ORCID: https://orcid.org/0000-0001-6259-7314)
- C. Jillian Tsai (ORCID: https://orcid.org/0009-0004-8051-0787)
- Achraf A. Shamseddine (ORCID: https://orcid.org/0000-0003-3686-5850)
- Jung Julie Kang (ORCID: https://orcid.org/0000-0001-9773-5481)
- Yingzhi Wu
- Caineng Cao
- Linda Chen (ORCID: https://orcid.org/0000-0001-7078-163X)
- Ian Ganly
Institutions
- University Health Network (CA)
- Siriraj Hospital (TH)
- Memorial Sloan Kettering Cancer Center (US)
- Mahidol University (TH)
- Princess Margaret Cancer Centre (CA)
- Yale University (US)
Publication Details
- Journal
- JAMA Otolaryngology–Head & Neck Surgery
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1001/jamaoto.2025.3214
- Citations
- 1
- Primary Topic
- Head and Neck Cancer Studies
- Type
- article
- Field-Weighted Citation Impact
- 1.85