Association Between Serum Cobalt and Manganese Levels with Insulin Resistance in Overweight and Obese Mexican Women

<b>Background:</b> Insulin resistance (IR) is common in overweight or obese individuals. Dysregulation of trace elements such as cobalt (Co) and manganese (Mn) has been associated with obesity and IR markers in individuals with diabetes. However, their role in non-diabetic states is less understood. <b>Objective:</b> This study aimed to analyze the association between serum Co and Mn levels and IR in overweight and obese women without diabetes. <b>Methods:</b> A total of 112 overweight or obese women were evaluated for their anthropometric, metabolic, and biochemical characteristics. To estimate IR, the homeostatic model assessment of insulin resistance (HOMA-IR), quantitative insulin sensitivity check index (QUICKI), triglyceride-glucose index (TyG), and triglyceride-glucose-body mass index (TyG-BMI) were calculated. Serum Co and Mn concentrations were quantified by inductively coupled plasma mass spectrometry (ICP-MS). <b>Results:</b> Our results show that 77% of participants exhibited central fat accumulation and a high prevalence of IR. Fasting insulin (FINS), HOMA-IR, and TyG-BMI were significantly higher in obese women, while adiponectin (Adpn) was lower. Moreover, Co was inversely associated with FINS (<i>p</i> = 0.003) and HOMA-IR (<i>p</i> = 0.011), and positively associated with QUICKI (<i>p</i> = 0.011) in obese women. In contrast, serum Mn levels showed negative correlations with fasting glucose (FG) (<i>p</i> = 0.021) and the TyG index (<i>p</i> = 0.048) in overweight women. <b>Conclusions:</b> Co serum levels were positively associated with FG and QUICKI and negatively associated with FINS and HOMA-IR in the obese group. Mn showed negative associations with FG and the TyG index, suggesting that these trace elements may play a role in the IR in people with obesity.