Association of HbA1c/HDL-C ratio and depression with cardiometabolic multimorbidity in middle-aged and older adults: a nationwide prospective cohort study
Both the HbA1c/HDL-C ratio and depression are independently associated with CMM. Depression did not mediate the association between the HbA1c/HDL-C ratio and CMM. Their combined effect substantially increases CMM risk, underscoring the importance of integrating metabolic and psychological assessments in early identification and personalized prevention strategies for high-risk populations.
Authors
- Xinyue Yang (ORCID: https://orcid.org/0000-0003-3928-5261)
- Aodi Huang (ORCID: https://orcid.org/0000-0003-0900-8570)
- Zhiqiang Zhang (ORCID: https://orcid.org/0000-0003-4692-7795)
- Wenjuan Zhang (ORCID: https://orcid.org/0000-0001-5955-3177)
- Jiayi Sun (ORCID: https://orcid.org/0009-0000-3224-3515)
- Jiayang Dong
Institutions
- Tianjin Medical University General Hospital (CN)
- Zhengzhou Central Hospital (CN)
- Tianjin Chest Hospital (CN)
Publication Details
- Journal
- Frontiers in Nutrition
- Published
- 2025-10-02
- DOI
- https://doi.org/10.3389/fnut.2025.1642243
- Citations
- 1
- Primary Topic
- Cardiovascular Function and Risk Factors
- Type
- article
- Field-Weighted Citation Impact
- 1.39