Pregnenolone and Progesterone: A Review of Their Roles in Reproductive Health, Sleep, Growth, Neurological Function, and Idiopathic Scoliosis

Pregnenolone and progesterone are essential steroid hormones that govern numerous physiological processes across the human lifespan. Traditionally viewed as reproductive hormones, their influence extends well beyond fertility and pregnancy, shaping neurological activity, sleep patterns, bone development, and even neuromotor control. In recent years, research has suggested that deficiencies or dysregulation of these hormones may contribute to adolescent idiopathic scoliosis (IS), a complex spinal condition of uncertain origin. This review synthesizes current scientific findings, highlighting the multifaceted roles of pregnenolone and progesterone and their potential therapeutic implications for both general health and spinal deformity prevention.