Investigation of the heterogeneity of cancer cells using single cell Ca2+ profiling
Our method demonstrates the potential of Ca<sup>2+</sup> profiling for discriminating cancer cells and predict their phenotypic characteristics at single cell level, and provides a framework for researchers to investigate the remodeling of the Ca<sup>2+</sup> signature during cancer development.
Authors
- Mathilde Cancel (ORCID: https://orcid.org/0000-0003-1162-214X)
- Christophe Vandier (ORCID: https://orcid.org/0000-0003-2559-0660)
- Dorine Bellanger (ORCID: https://orcid.org/0000-0002-8839-7844)
- Karine Mahéo
- David Crottès (ORCID: https://orcid.org/0000-0002-4038-6345)
- Gaëlle Fromont (ORCID: https://orcid.org/0000-0002-7730-2264)
- Maxime Guéguinou (ORCID: https://orcid.org/0000-0002-5793-2082)
- Camille Caussette
- Thierry Brouard (ORCID: https://orcid.org/0000-0002-9935-1411)
- Amélie E. Bura
- Alison Robert
- Margot Lacouette-Rata
Institutions
- Université de Tours (FR)
- Université d'Orléans (FR)
- Inserm (FR)
- Centre Hospitalier Universitaire de Tours (FR)
- Laboratoire d'Informatique Fondamentale et Appliquée de Tours (FR)
- Centre hospitalier universitaire d'Orléans (FR)
Publication Details
- Journal
- Cell Communication and Signaling
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1186/s12964-025-02417-3
- Primary Topic
- Ion channel regulation and function
- Type
- article
- Field-Weighted Citation Impact
- 0.00
Funders
- Institut National de la Santé et de la Recherche Médicale
- Ligue Contre le Cancer
- Ministère de l'Enseignement Supérieur et de la Recherche
- Studium Loire Valley-Institute for Advanced Studies