CAFs mediate carboplatin resistance in LUAD via CXCL12 secretion regulated by NF-κB activation
This study revealed that LUAD-derived CAFs activate the NF-κB axis to secrete CXCL12, thereby weakening the carboplatin's killing effect on LUAD. Furthermore, poorly differentiated LUAD secreted more CXCL12. These findings indicate a novel strategy to enhance carboplatin's chemotherapeutic potential against LUAD.
Authors
- Yang Song (ORCID: https://orcid.org/0000-0001-7993-8445)
- Yuanhan Wang
- Zeyang Yang (ORCID: https://orcid.org/0000-0003-0489-9132)
- Xu Zhu (ORCID: https://orcid.org/0000-0002-4623-8458)
- Zhu Zeng (ORCID: https://orcid.org/0000-0001-6198-7812)
- Long Li (ORCID: https://orcid.org/0000-0003-1037-0358)
- Jieheng Wu (ORCID: https://orcid.org/0000-0003-4927-3897)
- Xuanyin Wang (ORCID: https://orcid.org/0000-0002-6052-5015)
- Jiaming Ren
- Ying Zhang (ORCID: https://orcid.org/0000-0001-6320-8253)
- Xianling Zeng
- Lu Wang (ORCID: https://orcid.org/0000-0003-2525-4966)
- Jian Zhang (ORCID: https://orcid.org/0000-0002-9718-9748)
- Xinlei Liu (ORCID: https://orcid.org/0000-0001-7216-9292)
- Jiangwei Wu
- Qiaoling Zhang (ORCID: https://orcid.org/0000-0002-3713-5158)
- Jing Xiao (ORCID: https://orcid.org/0000-0002-9953-5878)
- Siyuan Yang (ORCID: https://orcid.org/0000-0002-0904-286X)
Institutions
- Guiyang Medical University (CN)
- Guizhou Cancer Hospital (CN)
- Affiliated Hospital of Guizhou Medical University (CN)
Publication Details
- Journal
- Cellular Oncology
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1007/s13402-025-01106-0
- Citations
- 1
- Primary Topic
- Chemokine receptors and signaling
- Type
- article
- Field-Weighted Citation Impact
- 1.05
Funders
- Health Commission of Guizhou Province
- National Natural Science Foundation of China
- Guizhou Medical University