The Depletion of Plasma Cells but Not <scp>CD20</scp> <sup>+</sup> B Cells Alleviates Primary Biliary Cholangitis
The data indicate a pathogenic role for plasma cells in PBC. The depletion of plasma cells alleviated cholangitis in PBC mice, indicating a promising new therapeutic strategy for PBC.
Authors
- Hui Yang (ORCID: https://orcid.org/0000-0003-0603-3834)
- Jiwen Li (ORCID: https://orcid.org/0000-0002-9066-0082)
- Bangmao Wang (ORCID: https://orcid.org/0000-0003-2796-1584)
- Ying Ran
- Jihua Shi (ORCID: https://orcid.org/0000-0002-9267-7523)
- Meng Shen (ORCID: https://orcid.org/0000-0002-1293-448X)
- Lu Zhou (ORCID: https://orcid.org/0000-0002-0424-7348)
- Hongyu Chu
- Xue Zhang (ORCID: https://orcid.org/0009-0003-2583-8977)
- Zhen Yang (ORCID: https://orcid.org/0000-0002-6851-5874)
- Long Li (ORCID: https://orcid.org/0000-0003-1670-4523)
- Xiaoyi Wang (ORCID: https://orcid.org/0000-0001-5766-0876)
- Yanni Li (ORCID: https://orcid.org/0000-0002-7021-9249)
- Zongze Han (ORCID: https://orcid.org/0009-0004-3188-5021)
- Hao Jia (ORCID: https://orcid.org/0000-0003-1856-6013)
- Man Liu (ORCID: https://orcid.org/0000-0001-5265-8224)
- Liping Guo (ORCID: https://orcid.org/0000-0002-0272-9802)
- Simin Zhou (ORCID: https://orcid.org/0000-0003-2981-1192)
- Shijing Dong
- Yujie Zhang (ORCID: https://orcid.org/0000-0002-5524-2790)
Institutions
- Chinese Academy of Medical Sciences & Peking Union Medical College (CN)
- Nankai University (CN)
- Tianjin First Center Hospital (CN)
- Tianjin Medical University General Hospital (CN)
- Tianjin Third Central Hospital (CN)
- Tianjin Medical University (CN)
Publication Details
- Journal
- Liver International
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1111/liv.70373
- Primary Topic
- Liver Diseases and Immunity
- Type
- article
- Field-Weighted Citation Impact
- 0.00