Supplementation of Tamoxifen with Low-Dose Endoxifen in Patients with Breast Cancer with Impaired Tamoxifen Metabolism (TAMENDOX): A Randomized Controlled Phase I/II Trial
Adding low-dose (Z)-endoxifen to standard tamoxifen is safe and provides a new approach to personalized antiestrogen treatment for patients with low endoxifen plasma levels.
Authors
- Denise Wrobel (ORCID: https://orcid.org/0009-0009-9040-8264)
- Matthew P. Goetz (ORCID: https://orcid.org/0000-0002-4383-270X)
- Lena Pfaff (ORCID: https://orcid.org/0009-0002-2495-8021)
- Hiltrud Brauch (ORCID: https://orcid.org/0000-0001-7531-2736)
- Simon Jäger (ORCID: https://orcid.org/0000-0003-3312-7596)
- Andreas Gerteis (ORCID: https://orcid.org/0009-0007-2484-8152)
- Inger Marie Bernhoft (ORCID: https://orcid.org/0009-0009-9559-8167)
- Svitlana Igel (ORCID: https://orcid.org/0009-0003-2311-0608)
- Werner Schroth (ORCID: https://orcid.org/0000-0003-1412-4592)
- Thomas E. Mürdter (ORCID: https://orcid.org/0000-0002-8786-8122)
- Matthias Schwab (ORCID: https://orcid.org/0000-0002-9984-075X)
- Elke Schaeffeler (ORCID: https://orcid.org/0009-0005-2997-0355)
- Christina Bechtner (ORCID: https://orcid.org/0009-0009-3543-9287)
- Roman Tremmel (ORCID: https://orcid.org/0000-0003-1564-0433)
- Sibylle Loibl (ORCID: https://orcid.org/0000-0001-6488-4958)
- Christoph Meisner (ORCID: https://orcid.org/0000-0002-4802-3100)
- Michael Block (ORCID: https://orcid.org/0009-0002-9902-7854)
- Imma Fischer (ORCID: https://orcid.org/0009-0006-9582-6244)
Institutions
- Mayo Clinic (US)
- German Cancer Research Center (DE)
- University of Cologne (DE)
- Robert Bosch Hospital (DE)
- Cardiovascular Center Bethanien (DE)
- Nuremberg Hospital (DE)
- National Center for Tumor Diseases (DE)
- Bamberg County Hospital (US)
- Paracelsus Medizinische Privatuniversität (DE)
- Dr. Margarete Fischer-Bosch-Institute of Clinical Pharmacology (DE)
- Research Institute for Work, Technology and Culture (DE)
- Breast Center (CH)
- Mayo Clinic in Arizona (US)
- University Children's Hospital Tübingen (DE)
- Stadtwerke Köln (Germany) (DE)
- German Breast group (DE)
- Hertie Institute for Clinical Brain Research (DE)
- Kernkraftwerk Gundremmingen (DE)
- Sozialstiftung Bamberg (DE)
- University Hospital Cologne (DE)
- University Hospital Ulm (DE)
- Bayer (Germany) (DE)
- University of Tübingen (DE)
- University of Bamberg (DE)
Publication Details
- Journal
- Clinical Cancer Research
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1158/1078-0432.ccr-25-2103
- Citations
- 2
- Primary Topic
- Estrogen and related hormone effects
- Type
- article
- Field-Weighted Citation Impact
- 3.63