Characterizing the Immune Response in Pig-to-Human Heart Xenografts Using a Multimodal Diagnostic System
Multimodal phenotyping of pig-to-human heart xenografts revealed early signs of xenoimmune response, characterized by mild innate microvascular inflammation, endothelial activation, and a molecular signature characteristic of antibody-mediated rejection. Developing such a precision diagnostic system could improve graft monitoring in future clinical settings.
Authors
- Thomas Kerforne (ORCID: https://orcid.org/0000-0002-0611-4100)
- Sébastien Giraud (ORCID: https://orcid.org/0000-0001-9015-8968)
- Michael DiVita (ORCID: https://orcid.org/0000-0003-4036-2893)
- David Ayares (ORCID: https://orcid.org/0000-0002-4638-3321)
- Anaïs Certain
- Aurélie Sannier (ORCID: https://orcid.org/0000-0003-3973-8793)
- Jacqueline I. Kim (ORCID: https://orcid.org/0000-0001-8165-525X)
- Alex Reyentovich (ORCID: https://orcid.org/0000-0002-1687-6053)
- Sameer Mehta (ORCID: https://orcid.org/0000-0002-5588-905X)
- Valentin Goutaudier (ORCID: https://orcid.org/0000-0001-6191-6889)
- Géraldine Allain (ORCID: https://orcid.org/0000-0002-0441-2956)
- Thierry Hauet (ORCID: https://orcid.org/0000-0002-0117-071X)
- Patrick Bruneval (ORCID: https://orcid.org/0000-0002-2350-2914)
- Tajinderpal Saraon (ORCID: https://orcid.org/0000-0002-2186-1921)
- Alessia Giarraputo (ORCID: https://orcid.org/0000-0003-4070-7943)
- Robert A. Montgomery (ORCID: https://orcid.org/0000-0003-2728-4552)
- Massimo Mangiola (ORCID: https://orcid.org/0000-0002-5406-4005)
- Erwan Morgand (ORCID: https://orcid.org/0000-0002-1064-8770)
- Navneet Narula (ORCID: https://orcid.org/0000-0002-6832-3645)
- Jeffrey Stern (ORCID: https://orcid.org/0000-0001-5588-0357)
- Guillaume Coutance (ORCID: https://orcid.org/0000-0003-4939-2175)
- Adam Griesemer (ORCID: https://orcid.org/0000-0003-4894-2024)
- Fariza Mezine
- Alexandre Loupy (ORCID: https://orcid.org/0000-0003-3388-7747)
- Renaud Tissier (ORCID: https://orcid.org/0000-0001-6602-939X)
- Deane E. Smith (ORCID: https://orcid.org/0000-0003-0983-6739)
- Bernard Kadosh (ORCID: https://orcid.org/0000-0003-2069-1534)
- Nader Moazami (ORCID: https://orcid.org/0000-0001-5306-070X)
- Randal Goldberg (ORCID: https://orcid.org/0000-0001-8173-3414)
- Harvey I. Pass (ORCID: https://orcid.org/0000-0003-3222-3471)
- Karen Khalil (ORCID: https://orcid.org/0000-0001-7350-0418)
Institutions
- Inserm (FR)
- École Nationale Vétérinaire d'Alfort (FR)
- Université Paris Cité (FR)
- Université de Poitiers (FR)
- Paris Cardiovascular Research Center (FR)
- Miami Transplant Institute (US)
- Institut Mondor de Recherche Biomédicale (FR)
- Virginia Tech (US)
Publication Details
- Journal
- Circulation
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1161/circulationaha.125.074971
- Citations
- 4
- Primary Topic
- Xenotransplantation and immune response
- Type
- article
- Field-Weighted Citation Impact
- 8.03