HLA-focused type 1 diabetes genetic risk prediction in populations of diverse ancestry
T1D GRS<sub>HLA</sub> models derived from SNPs performed equivalently to those derived from HLA alleles across ancestries. In addition, T1D GRS<sub>HLA-SNP-ALL</sub> and GRS<sub>HLA-allele-ALL</sub> models had consistently high ROC AUC values when applied across ancestry groups. Larger studies in more diverse populations are needed to better assess the transferability of T1D GRS<sub>HLA</sub> across ancestries.
Authors
- Courtney Tern (ORCID: https://orcid.org/0000-0001-5029-595X)
- Catherine C. Robertson (ORCID: https://orcid.org/0000-0002-1120-1786)
- Dominika A. Michalek (ORCID: https://orcid.org/0000-0002-0634-0319)
- Stephen S. Rich (ORCID: https://orcid.org/0000-0003-3872-7793)
- Suna Önengüt-Gümüşcü (ORCID: https://orcid.org/0000-0002-6563-8334)
- Wei‐Min Chen (ORCID: https://orcid.org/0000-0002-2643-2333)
Institutions
- Brigham and Women's Hospital (US)
- University of Michigan (US)
- University of Virginia (US)
Publication Details
- Journal
- Diabetologia
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1007/s00125-025-06563-8
- Citations
- 2
- Primary Topic
- Diabetes and associated disorders
- Type
- article
- Field-Weighted Citation Impact
- 3.63