Profiling the real-world migraine patient: public health insights from sociodemographic, lifestyle, and clinical data in the Italian National Migraine Registry (I-GRAINE)
The typical patient attending Italian headache centers is a 45-year-old, normal-weight, well-educated, employed woman, often physically inactive, affected by sleep disturbances, and experiencing an average of 9.8 migraine days/month. I-GRAINE identifies migraine symptoms that may represent endophenotypes and distinct patterns associated with CM, offering valuable real-world insights to inform personalized care, research, and health policy.
Authors
- Gian Luca Vita (ORCID: https://orcid.org/0000-0003-4190-8042)
- Massimo Filippi (ORCID: https://orcid.org/0000-0002-5485-0479)
- Cinzia Aurilia (ORCID: https://orcid.org/0000-0002-2658-2243)
- Maria Albanese (ORCID: https://orcid.org/0000-0002-5113-2017)
- Annalisa Gai
- Piero Barbanti (ORCID: https://orcid.org/0000-0002-5670-3755)
- Micaela Robotti
- Prabha Cristina Ranchicchio
- Gennaro Alfieri
- Roberta Messina (ORCID: https://orcid.org/0000-0003-4421-0432)
- Davide Mascarella (ORCID: https://orcid.org/0000-0002-9265-3281)
- Sabina Cevoli (ORCID: https://orcid.org/0000-0003-4668-4295)
- G. Sixt
- Pietro Antonio Bruno (ORCID: https://orcid.org/0000-0002-2717-2385)
- Francesca Pistoia (ORCID: https://orcid.org/0000-0003-0790-4240)
- Pietro Querzani (ORCID: https://orcid.org/0000-0003-0492-5759)
- Federica Genovese (ORCID: https://orcid.org/0000-0003-1984-1881)
- Alessandro Cocuzza (ORCID: https://orcid.org/0000-0002-8071-2985)
- Mattia Sansone (ORCID: https://orcid.org/0000-0002-1232-2651)
- Arianna Deidda
- Massimo Autunno (ORCID: https://orcid.org/0000-0002-7526-2799)
- Francesco Bono (ORCID: https://orcid.org/0000-0002-4650-6635)
- Laura Zanandrea
- Stefano Bonassi (ORCID: https://orcid.org/0000-0003-3833-6717)
- Claudio Gambini
- Ilaria Cetta (ORCID: https://orcid.org/0000-0002-9493-3885)
- Giacomo Querzola (ORCID: https://orcid.org/0000-0002-9725-5370)
- Lorenzo Forino
- Gennaro Saporito (ORCID: https://orcid.org/0009-0001-2390-0533)
- Davide Mantica
- Maurizio Zucco
- Angelo Ranieri (ORCID: https://orcid.org/0000-0001-5450-1909)
- Giovanna Viticchi (ORCID: https://orcid.org/0000-0002-1799-1563)
- Licia Grazzi (ORCID: https://orcid.org/0000-0001-6535-1109)
- Alberto Gotti
- Paolo Solla (ORCID: https://orcid.org/0000-0002-2982-0665)
- Vittoria Carla D’Agostino
- Francesco Tazza (ORCID: https://orcid.org/0000-0002-3515-3475)
- Pamela Silva
- Domenico Cosenza
- Giulia Bozzo
- Roberto De Simone (ORCID: https://orcid.org/0000-0002-0954-8668)
- Paola Torelli (ORCID: https://orcid.org/0000-0002-4072-2353)
- Carlo Tomino (ORCID: https://orcid.org/0000-0003-1823-2195)
- Marco Aguggia
- Tommaso Ercoli (ORCID: https://orcid.org/0000-0002-3260-1754)
- Fabio Frediani
- Simone Cesarano (ORCID: https://orcid.org/0000-0003-4200-837X)
- Alfonsina Di Summa
- Simone Braca (ORCID: https://orcid.org/0000-0002-9733-8344)
- B Colombo (ORCID: https://orcid.org/0000-0003-3064-0917)
- Bianca Orlando
- Francesca Cortese (ORCID: https://orcid.org/0000-0001-9791-1537)
- Barbara Petolicchio (ORCID: https://orcid.org/0000-0003-2775-928X)
- Francesco Zoroddu
- Alfonso Coppola
- M. De Luca (ORCID: https://orcid.org/0009-0006-4913-9232)
- Cecilia Camarda
- Annamaria Porreca (ORCID: https://orcid.org/0000-0003-3278-1561)
- Gabriella Egeo (ORCID: https://orcid.org/0000-0003-3068-4522)
- Carlo Colosimo (ORCID: https://orcid.org/0000-0002-2216-3973)
- Giulia Pierangeli
- Cinzia Finocchi (ORCID: https://orcid.org/0000-0003-4385-1203)
- Marco Russo (ORCID: https://orcid.org/0000-0001-5171-8555)
- Ludovica Ferraù
- Marilena Marcosano (ORCID: https://orcid.org/0009-0003-5191-7628)
- Steno Rinalduzzi
- Vincenzo Andreone (ORCID: https://orcid.org/0000-0002-9590-9414)
- Rosario Grugno (ORCID: https://orcid.org/0009-0000-9700-2157)
- Stefania Proietti (ORCID: https://orcid.org/0000-0002-9844-1482)
- Alberto Doretti (ORCID: https://orcid.org/0000-0002-1015-7365)
- I. Pestalozza
- L. Borrello (ORCID: https://orcid.org/0000-0001-6801-7966)
- Francesca Gragnani
- Stefano Caproni (ORCID: https://orcid.org/0000-0002-8627-9879)
- Simone Quintana (ORCID: https://orcid.org/0000-0001-8160-0339)
- Valentina Favoni
- Nicola Biagio Mercuri (ORCID: https://orcid.org/0000-0001-6700-7491)
- Giulia Fiorentini
- Marco Bartolini (ORCID: https://orcid.org/0000-0003-2518-6369)
- Fabrizio Vernieri (ORCID: https://orcid.org/0000-0002-9594-9336)
- Marco Tiriticco
- Stefano Messina (ORCID: https://orcid.org/0009-0009-4538-7476)
- Francesco Perini (ORCID: https://orcid.org/0000-0002-5721-3969)
- Elisabetta Iannaccone
- Nicoletta Brunelli (ORCID: https://orcid.org/0000-0002-8590-9015)
- Rossana Terlizzi
- Sofia Tavani
- Laura Di Clemente (ORCID: https://orcid.org/0000-0002-2426-1163)
- Eleonora Colombo (ORCID: https://orcid.org/0000-0003-0689-2989)
- Enrica Maria Puddu
- Monica Laura Bandettini di Poggio
- Paola Scatena
- Riccardo Lo Presti
- Renata Rao
- Florindo d’Onofrio (ORCID: https://orcid.org/0009-0007-1647-3389)
- Antonio Carnevale (ORCID: https://orcid.org/0009-0005-5665-5780)
- Mariamichela Aquino
- Aurora Masia
- A. Cherchi
- Chiara Serafini
- Paolo Vallarino
- Sara Cazzulo
- Martina Guarinoni
- Alice Laffranchi
Institutions
- University of Messina (IT)
- University of Rome Tor Vergata (IT)
- Marche Polytechnic University (IT)
- University of Parma (IT)
- Vita-Salute San Raffaele University (IT)
- Università Campus Bio-Medico (IT)
- University of Sassari (IT)
- University of Cagliari (IT)
- University of L'Aquila (IT)
- Santa Maria Nuova Hospital (IT)
- Agostino Gemelli University Polyclinic (IT)
- San Raffaele University of Rome (IT)
- Azienda Sanitaria Unità Locale di Reggio Emilia (IT)
- Ospedale di Bolzano (IT)
- Ospedale "Santa Maria delle Croci" di Ravenna (IT)
- Ellis Hospital (US)
- Ospedale San Filippo Neri (IT)
- Ospedale San Carlo (IT)
- Azienda Socio Sanitaria Territoriale degli Spedali Civili di Brescia (IT)
- Azienda Sanitaria Locale di Asti (IT)
- Azienda Ospedaliera S.Giuseppe Moscati (IT)
- Ospedale “M. Bufalini” di Cesena (IT)
- Federico II University Hospital (IT)
- Istituto delle Scienze Neurologiche di Bologna (IT)
- IRCCS Ospedale San Raffaele (IT)
- IRCCS Istituto Auxologico Italiano (IT)
- Ospedale Sandro Pertini (IT)
- Campus Bio Medico University Hospital (IT)
- Ospedale Policlinico San Martino (IT)
- Azienda Sanitaria Locale N. 2 Savonese (IT)
- Ospedale San Bortolo (IT)
- Carlo Forlanini Hospital (IT)
- Istituti di Ricovero e Cura a Carattere Scientifico (IT)
- Centro Neurolesi Bonino Pulejo (IT)
- Ospedale Santa Corona (IT)
- Fondazione IRCCS Istituto Neurologico Carlo Besta (IT)
- Istituto di Ricovero e Cura a Carattere Scientifico San Raffaele (IT)
- University of Brescia (IT)
- University of Genoa (IT)
- University of Palermo (IT)
- European Automobile Manufacturers Association (BE)
Publication Details
- Journal
- The Journal of Headache and Pain
- Published
- 2025-10-02
- DOI
- https://doi.org/10.1186/s10194-025-02146-5
- Citations
- 4
- Primary Topic
- Migraine and Headache Studies
- Type
- article
- Field-Weighted Citation Impact
- 5.88
Funders
- Amgen
- Bristol-Myers Squibb
- Eli Lilly and Company
- Pfizer
- Sanofi
- Biogen
- Teva Pharmaceutical Industries
- Alexion Pharmaceuticals
- Celgene
- Fondazione Italiana Sclerosi Multipla
- Ministero della Salute
- Novo Nordisk
- Fondazione Italiana di Ricerca per la Sclerosi Laterale Amiotrofica
- H. Lundbeck A/S
- Ipsen